Oncogene PKCε controls INrf2:Nrf2 interaction in normal and cancer cells through INrf2 phosphorylation
نویسندگان
چکیده
منابع مشابه
Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2.
The INrf2 (Keap1)-Nrf2 cell sensor complex has a crucial role in protection against chemical- and radiation-induced oxidative stress and cellular transformation. INrf2, in association with Cul3-Rbx1, ubiquitylates and degrades Nrf2. Exposure to stressors leads to stabilization of Nrf2 and the coordinated activation of cytoprotective proteins and cellular protection. However, the molecular signa...
متن کاملOncogene PKCε controls INrf2:Nrf2 interaction in normal and cancer cells through INrf2 phosphorylation
The INrf2 (Keap1):Nrf2 complex plays a critical role in protection against chemical and radiationinduced oxidative stress and cellular transformation. INrf2 in association with Cul3-Rbx1 ubiquitinylates and degrades Nrf2. Exposure to stressors leads to Nrf2 stabilization and coordinated activation of cytoprotective proteins and cellular protection. However, the molecular signal(s) that regulate...
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INrf2 (Keap1) serves as a negative regulator of the cytoprotective transcription factor Nrf2. At basal levels, INrf2 functions as a substrate adaptor to sequester Nrf2 into the Cul3-Rbx1 E3 ligase complex for ubiquitylation and proteasomal degradation. In response to antioxidants, Nrf2 is released from the INrf2-Cul3-Rbx1 complex and translocates into the nucleus, where it activates ARE-mediate...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2013
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.133819